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Applied and Environmental Microbiology, February 2009, p. 837-841, Vol. 75, No. 3
0099-2240/09/$08.00+0     doi:10.1128/AEM.01299-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Structural and Molecular Basis of the Role of Starch and Sucrose in Streptococcus mutans Biofilm Development{triangledown} ,{dagger}

M. I. Klein,1 S. Duarte,1,{ddagger} J. Xiao,1 S. Mitra,3 T. H. Foster,3 and H. Koo1,2*

Eastman Department of Dentistry and Center for Oral Biology,1 Department of Microbiology and Immunology,2 Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York3

Received 11 June 2008/ Accepted 17 November 2008

The interaction of sucrose and starch with bacterial glucosyltransferases and human salivary amylase may enhance the pathogenic potential of Streptococcus mutans within biofilms by influencing the structural organization of the extracellular matrix and modulating the expression of genes involved in exopolysaccharide synthesis and specific sugar transport and two-component systems.

* Corresponding author. Mailing address: University of Rochester Medical Center, Eastman Department of Dentistry and Center for Oral Biology, 625 Elmwood Ave., Box 683, Rochester, NY 14620. Phone: (585) 273-4216. Fax: (585) 276-0190. E-mail: Hyun_Koo{at}urmc.rochester.edu

{triangledown} Published ahead of print on 21 November 2008.

{dagger} Supplemental material for this article may be found at http://aem.asm.org/.

{ddagger} Present address: New York University College of Dentistry, Department of Basic Sciences, Room 902B, 345 E. 24th Street, New York, NY 10010.

Applied and Environmental Microbiology, February 2009, p. 837-841, Vol. 75, No. 3
0099-2240/09/$08.00+0     doi:10.1128/AEM.01299-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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