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Applied and Environmental Microbiology, February 2009, p. 872-874, Vol. 75, No. 3
0099-2240/09/$08.00+0     doi:10.1128/AEM.01831-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci{triangledown}

Marianne Horgan,1,2 Gary O’Flynn,1,2 Jennifer Garry,1,3 Jakki Cooney,4 Aidan Coffey,3 Gerald F. Fitzgerald,2,5 R. Paul Ross,1,5* and Olivia McAuliffe1

Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland,1 Department of Microbiology, University College Cork, Cork, Ireland,2 Department of Biological Sciences, Cork Institute of Technology, Cork, Ireland,3 Department of Life Sciences, Materials and Surface Science Institute, University of Limerick, Limerick, Ireland,4 Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland5

Received 7 August 2008/ Accepted 15 November 2008

A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

* Corresponding author. Mailing address: Biotechnology Centre, Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland. Phone: 353 (0)25 42229. Fax: 353 (0)25 42340. E-mail: paul.ross{at}teagasc.ie

{triangledown} Published ahead of print on 1 December 2008.

Applied and Environmental Microbiology, February 2009, p. 872-874, Vol. 75, No. 3
0099-2240/09/$08.00+0     doi:10.1128/AEM.01831-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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