Response of wild-type and resistant strains of the hyperthermophilic bacterium Thermotoga maritima to chloramphenicol challenge

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905

^* To whom correspondence should be addressed. Email: rmkelly{at}eos.ncsu.edu.

	Abstract

Transcriptomes and growth physiology of the hyperthermophile Thermotoga maritima and an antibiotic-resistant, spontaneous mutant were compared prior to and following exposure to chloramphenicol. While the wild-type response was similar to mesophilic bacteria, reduced susceptibility of the mutant was attributed to five mutations in 23S rRNA and phenotypic pre-conditioning to chloramphenicol.