AEM Accepts, published online ahead of print on 6 April 2007

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Appl. Environ. Microbiol. doi:10.1128/AEM.00666-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Salivaricin P: one of a family of two component anti-listerial bacteriocins produced by intestinal isolates of Lactobacillus salivarius

Eoin Barrett, Maria Hayes, Paula O'Connor, Gillian Gardiner, Gerald Fitzgerald, Catherine Stanton, R. Paul Ross^*, and Colin Hill

Teagasc Biotechnology Centre, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland; Alimentary Pharmabiotic Centre, Biosciences Institute and; Department of Microbiology, University College Cork

^* To whom correspondence should be addressed. Email: paul.ross{at}teagasc.ie.

Lactobacillus salivarius DPC6005, a porcine intestinal isolate, produces a two-component bacteriocin, Salivaricin P, with homology to ABP-118 produced by a human probiotic Lb. salivarius strain. Indeed, molecular characterization revealed that while the peptides Sln1 and ABP-118 are identical; their respective companion peptides (Sln2 and ABP-118 ) differed by two amino acids. This observation suggests that two-component bacteriocins may be a common feature of intestinal Lb. salivarius strains.