Appl. Environ. Microbiol. doi:10.1128/AEM.00666-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.
Salivaricin P: one of a family of two component anti-listerial bacteriocins produced by intestinal isolates of Lactobacillus salivarius
Eoin Barrett,
Maria Hayes,
Paula O'Connor,
Gillian Gardiner,
Gerald Fitzgerald,
Catherine Stanton,
R. Paul Ross*,
and
Colin Hill
Teagasc Biotechnology Centre, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland; Alimentary Pharmabiotic Centre, Biosciences Institute and; Department of Microbiology, University College Cork
* To whom correspondence should be addressed. Email:
paul.ross{at}teagasc.ie.
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Abstract |
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Lactobacillus salivarius DPC6005, a porcine intestinal isolate, produces a two-component bacteriocin, Salivaricin P, with homology to ABP-118 produced by a human probiotic Lb. salivarius strain. Indeed, molecular characterization revealed that while the peptides Sln1 and ABP-118
are identical; their respective companion peptides (Sln2 and ABP-118
) differed by two amino acids. This observation suggests that two-component bacteriocins may be a common feature of intestinal Lb. salivarius strains.