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Appl. Environ. Microbiol. doi:10.1128/AEM.02512-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

A Legionella pneumophila peptidyl-prolyl cis-trans isomerase present in culture supernatants is necessary for optimal growth at low temperatures

Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois 60611

^* To whom correspondence should be addressed. Email: n-cianciotto{at}northwestern.edu.

	Abstract

Several Legionella pneumophila proteins were highly expressed in low-temperature supernatants. One was PPIase PpiB. Mutants lacking ppiB exhibited reduced growth at 17°C. Since PpiB lacked a signal sequence and was in 17°C supernatants of type II and type IV secretion mutants, the protein may be secreted by a novel mechanism.