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Appl. Environ. Microbiol. doi:10.1128/AEM.02576-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

High yield production of secreted active proteins by the Pseudomonas aeruginosa type III secretion system

Laboratoire TIMC-IMAG GREPI-TheREx, Université Joseph Fourier – Grenoble 1 UMR CNRS 5525, IFR INSERM 130

^* To whom correspondence should be addressed. Email: BPolack{at}chu-grenoble.fr.

	Abstract

E. coli is the system of choice for recombinant protein production because it is possible to obtain high protein yield in inexpensive media. The accumulation of protein in an insoluble form in inclusion bodies remains a major disadvantage. The use of the P. aeruginosa type III secretion system can avoid this problem, allowing the production of soluble secreted proteins.