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Appl. Environ. Microbiol. doi:10.1128/AEM.02670-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Shedding of Escherichia coli O157:H7 in Calves is Reduced by Prior Colonization with the Homologous Strain

Animal Health Group, Scottish Agricultural College, West Mains Road, Edinburgh, EH9 3JG, United Kingdom; Center for Infectious Diseases, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom; Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, United Kingdom

^* To whom correspondence should be addressed. Email: stuart.naylor{at}sac.ac.uk.

	Abstract

Enterohemorrhagic Escherichia coli O157:H7 has a natural reservoir in the intestinal tracts of cattle. Colonization is asymptomatic and transient but it is not clear if protective immunity is induced. This study demonstrates that prior colonization induces humoral immune responses to bacterial antigens and reduces bacterial shedding after homologous experimental challenge.