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AEM Accepts, published online ahead of print on 13 April 2007
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Appl. Environ. Microbiol. doi:10.1128/AEM.02804-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Quorum Sensing Enhances Stress Response in Vibrio cholerae

Adam Joelsson, Biao Kan, and Jun Zhu*

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104; State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Beijing, China

* To whom correspondence should be addressed. Email: junzhu{at}mail.med.upenn.edu.


  Abstract

Vibrio cholerae lives in aquatic environments and causes cholera. Here we show that quorum sensing enhances V. cholerae viability under certain stress conditions by upregulating the expression of RpoS and this regulation acts through HapR, suggesting that quorum sensing enhanced stress response plays a role in V. cholerae environmental survival.


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