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Appl. Environ. Microbiol. doi:10.1128/AEM.02809-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Thiols in a Nitric Oxide Synthase-Containing Nocardia sp. NRRL 5646

Sungwon Lee, Hélène Bergeron, Peter C. K. Lau, and John P. N. Rosazza*

Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Center for Biocatalysis and Bioprocessing, The University of Iowa, Iowa City, Iowa 52242; Biotechnology Research Institute, National Research Council Canada, 6100 Royalmount Ave, Montreal, Quebec, Canada H4P 2R2

* To whom correspondence should be addressed. Email: john-rosazza{at}uiowa.edu.


  Abstract

Mycothiol (MSH, 1-D-myo-inosityl-2-(N-acetyl-L-cysteinyl)amido-2-deoxy-{alpha}-D-glucopyranoside), isolated as the bimane derivative, was established to be the major thiol in Nocardia sp. NRRL 5646, a species most closely related to N. brasiliensis strain DSM 43758T. Thiol formation and detection of MSH-dependent formaldehyde dehydrogenase activity in cell-free extracts are relevant to possible modulation of nitric oxide toxicity generated by strain NRRL 5646.




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