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Appl. Environ. Microbiol. doi:10.1128/AEM.02842-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Aspergillus nidulans Natural Product Biosynthesis is Regulated by MpkB, a Putative Pheromone-Response MAP-Kinase

Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA

	Abstract

The Aspergillus nidulans putative MAP-kinase mpkB has a role in natural product biosynthesis. The mpkB mutant presented a decrease in sterigmatocystin gene expression and low mycotoxin levels. This mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA, described to regulate secondary metabolism gene clusters.