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Antimicrobial Agents and Chemotherapy

Some Active Derivatives of Penicillin

Loman D. Brown, Walter A. Zygmunt, Homer E. Stavely
Loman D. Brown
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Walter A. Zygmunt
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Homer E. Stavely
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ABSTRACT

The antibacterial activities of a number of amide derivatives of penicillin against both penicillin-sensitive and penicillin-resistant cultures were determined. Several of them were found to possess significant inhibitory activity against certain gram-positive bacteria. The amides, although resistant to the destructive action of β-lactamase, did not protect G in competitive experiments. One derivative, the O-benzylhydroxamide of penicillin G, was active against six or eight penicillin-resistant strains of Staphylococcus aureus (minimal inhibitory concentration, 0.2 μg/ml or less), but was found to have only a minimal in vivo activity against mouse Streptococcus infections.

FOOTNOTES

  • ↵1 Present address: The J. M. Smucker Co., P. O. Box 280, Orrville, Ohio 44667.

  • ↵2 Present address: Medical College of Ohio at Toledo, Toledo, Ohio 43614.

  • Copyright © 1969 American Society for Microbiology
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Some Active Derivatives of Penicillin
Loman D. Brown, Walter A. Zygmunt, Homer E. Stavely
Applied Microbiology Mar 1969, 17 (3) 339-343; DOI:

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Some Active Derivatives of Penicillin
Loman D. Brown, Walter A. Zygmunt, Homer E. Stavely
Applied Microbiology Mar 1969, 17 (3) 339-343; DOI:
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