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Clinical Microbiology, Virology, and Immunology

Immunogenicity of Nanogram to Milligram Quantities of Inactivated Foot-and-Mouth Disease Virus. I. Relative Virus-neutralizing Potency of Guinea Pig Sera

D. O. Morgan, H. L. Bachrach, P. D. McKercher
D. O. Morgan
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H. L. Bachrach
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P. D. McKercher
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ABSTRACT

Quantitative antigen dose-neutralizing antibody response curves were established in guinea pigs for purified foot-and-mouth disease virus (FMDV), type A, strain 119, inactivated for 48 hr with N-acetylethyleneimine (AEI). Inactivation of FMDV by 0.05% AEI at 25 C occurred without virus degradation and followed first-order kinetics over a 108-fold decrease in plaque-forming units (PFU) extrapolating to 10-5 PFU/ml at 48 hr. The AEI-treated virus was administered in doses ranging from 10 ng to 2.62 mg, alone or emulsified in oil adjuvant. Sigmoidal dose-response curves were obtained with 160 ng as the minimum effective dose. The maximum effective dose was 163 μg and 2.62 mg or more at 6 and 28 through 84 days postinoculation, respectively. Oil adjuvant had little effect at 6 days postinoculation, but its use markedly increased the amount of neutralizing antibody obtained at the later testing periods.

  • Copyright © 1969 American Society for Microbiology
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Immunogenicity of Nanogram to Milligram Quantities of Inactivated Foot-and-Mouth Disease Virus. I. Relative Virus-neutralizing Potency of Guinea Pig Sera
D. O. Morgan, H. L. Bachrach, P. D. McKercher
Applied Microbiology Mar 1969, 17 (3) 441-445; DOI:

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Immunogenicity of Nanogram to Milligram Quantities of Inactivated Foot-and-Mouth Disease Virus. I. Relative Virus-neutralizing Potency of Guinea Pig Sera
D. O. Morgan, H. L. Bachrach, P. D. McKercher
Applied Microbiology Mar 1969, 17 (3) 441-445; DOI:
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