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Mycology

Conidial Hydrophobins of Aspergillus fumigatus

Sophie Paris, Jean-Paul Debeaupuis, Reto Crameri, Marilyn Carey, Franck Charlès, Marie Christine Prévost, Christine Schmitt, Bruno Philippe, Jean Paul Latgé
Sophie Paris
1Unité des Aspergillus, Département Structure et Dynamique des génomes
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  • For correspondence: sparis@pasteur.fr
Jean-Paul Debeaupuis
1Unité des Aspergillus, Département Structure et Dynamique des génomes
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Reto Crameri
2Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
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Marilyn Carey
3Gatan, Oxford, United Kingdom
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Franck Charlès
4Jeol Europe, Croissy-sur-Seine, France
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Marie Christine Prévost
5Plateforme de Microscopie électronique, Institut Pasteur, Paris
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Christine Schmitt
5Plateforme de Microscopie électronique, Institut Pasteur, Paris
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Bruno Philippe
1Unité des Aspergillus, Département Structure et Dynamique des génomes
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Jean Paul Latgé
1Unité des Aspergillus, Département Structure et Dynamique des génomes
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DOI: 10.1128/AEM.69.3.1581-1588.2003
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ABSTRACT

The surface of Aspergillus fumigatus conidia, the first structure recognized by the host immune system, is covered by rodlets. We report that this outer cell wall layer contains two hydrophobins, RodAp and RodBp, which are found as highly insoluble complexes. The RODA gene was previously characterized, and ΔrodA conidia do not display a rodlet layer (N. Thau, M. Monod, B. Crestani, C. Rolland, G. Tronchin, J. P. Latgé, and S. Paris, Infect. Immun. 62:4380-4388, 1994). The RODB gene was cloned and disrupted. RodBp was highly homologous to RodAp and different from DewAp of A. nidulans. ΔrodB conidia had a rodlet layer similar to that of the wild-type conidia. Therefore, unlike RodAp, RodBp is not required for rodlet formation. The surface of ΔrodA conidia is granular; in contrast, an amorphous layer is present at the surface of the conidia of the ΔrodA ΔrodB double mutant. These data show that RodBp plays a role in the structure of the conidial cell wall. Moreover, rodletless mutants are more sensitive to killing by alveolar macrophages, suggesting that RodAp or the rodlet structure is involved in the resistance to host cells.

  • Copyright © 2003 American Society for Microbiology
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Conidial Hydrophobins of Aspergillus fumigatus
Sophie Paris, Jean-Paul Debeaupuis, Reto Crameri, Marilyn Carey, Franck Charlès, Marie Christine Prévost, Christine Schmitt, Bruno Philippe, Jean Paul Latgé
Applied and Environmental Microbiology Mar 2003, 69 (3) 1581-1588; DOI: 10.1128/AEM.69.3.1581-1588.2003

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Conidial Hydrophobins of Aspergillus fumigatus
Sophie Paris, Jean-Paul Debeaupuis, Reto Crameri, Marilyn Carey, Franck Charlès, Marie Christine Prévost, Christine Schmitt, Bruno Philippe, Jean Paul Latgé
Applied and Environmental Microbiology Mar 2003, 69 (3) 1581-1588; DOI: 10.1128/AEM.69.3.1581-1588.2003
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KEYWORDS

Aspergillus fumigatus
Fungal Proteins

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