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Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

Xiaoxue Wang, Thomas K. Wood
Xiaoxue Wang
1Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843-3122
2Key Laboratory of Marine Bio-Resource Sustainable Utilization, the South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, People's Republic of China
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Thomas K. Wood
1Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843-3122
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  • For correspondence: Thomas.Wood@chemail.tamu.edu
DOI: 10.1128/AEM.05068-11
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ABSTRACT

In many genomes, toxin-antitoxin (TA) systems have been identified; however, their role in cell physiology has been unclear. Here we examine the evidence that TA systems are involved in biofilm formation and persister cell formation and that these systems may be important regulators of the switch from the planktonic to the biofilm lifestyle as a stress response by their control of secondary messenger 3′,5′-cyclic diguanylic acid. Specifically, upon stress, the sequence-specific mRNA interferases MqsR and MazF mediate cell survival. In addition, we propose that TA systems are not redundant, as they may have developed to respond to specific stresses.

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Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response
Xiaoxue Wang, Thomas K. Wood
Applied and Environmental Microbiology Aug 2011, 77 (16) 5577-5583; DOI: 10.1128/AEM.05068-11

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Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response
Xiaoxue Wang, Thomas K. Wood
Applied and Environmental Microbiology Aug 2011, 77 (16) 5577-5583; DOI: 10.1128/AEM.05068-11
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