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Applied and Environmental Microbiology
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Food Microbiology

Novel Probiotic Bifidobacterium longum subsp. infantis CECT 7210 Strain Active against Rotavirus Infections

José Antonio Moreno Muñoz, Empar Chenoll, Beatriz Casinos, Esther Bataller, Daniel Ramón, Salvador Genovés, Rebeca Montava, Juan Manuel Ribes, Javier Buesa, Joan Fàbrega, Montserrat Rivero
José Antonio Moreno Muñoz
Laboratorios Ordesa S.L., Parc Científic de Barcelona, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain
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  • For correspondence: josea.moreno@ordesa.es
Empar Chenoll
Department of Food Biotechnology, Biópolis S.L., Parc Científic Universitat de València, C/Catedrático Agustín Escardino 9, Edificio 2, 46980 Paterna, Valencia, Spain
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Beatriz Casinos
Department of Food Biotechnology, Biópolis S.L., Parc Científic Universitat de València, C/Catedrático Agustín Escardino 9, Edificio 2, 46980 Paterna, Valencia, Spain
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Esther Bataller
Department of Food Biotechnology, Biópolis S.L., Parc Científic Universitat de València, C/Catedrático Agustín Escardino 9, Edificio 2, 46980 Paterna, Valencia, Spain
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Daniel Ramón
Department of Food Biotechnology, Biópolis S.L., Parc Científic Universitat de València, C/Catedrático Agustín Escardino 9, Edificio 2, 46980 Paterna, Valencia, Spain
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Salvador Genovés
Department of Food Biotechnology, Biópolis S.L., Parc Científic Universitat de València, C/Catedrático Agustín Escardino 9, Edificio 2, 46980 Paterna, Valencia, Spain
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Rebeca Montava
Department of Microbiology, School of Medicine, University of Valencia, and Hospital Clínico Universitario, 46010 Valencia, Spain
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Juan Manuel Ribes
Department of Microbiology, School of Medicine, University of Valencia, and Hospital Clínico Universitario, 46010 Valencia, Spain
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Javier Buesa
Department of Microbiology, School of Medicine, University of Valencia, and Hospital Clínico Universitario, 46010 Valencia, Spain
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Joan Fàbrega
Laboratorios Ordesa S.L., Parc Científic de Barcelona, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain
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Montserrat Rivero
Laboratorios Ordesa S.L., Parc Científic de Barcelona, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain
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DOI: 10.1128/AEM.05548-11
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ABSTRACT

Rotavirus is the leading cause of severe acute gastroenteritis among children worldwide. It is well known that breast-feeding and vaccination afford infants protection. Since breast-feeding has drastically decreased in developed countries, efforts have been focused on the potential use of probiotics as preventive agents. In this study, a novel Bifidobacterium longum subsp. infantis strain was isolated from infant feces and selected, based on its capacity to inhibit in vitro rotavirus Wa replication (up to 36.05% infectious foci reduction) and also to protect cells from virus infection (up to 48.50% infectious foci reduction) in both MA-104 and HT-29 cell lines. Furthermore, studies using a BALB/c mouse model have proved that this strain provides preliminary in vivo protection against rotavirus infection. The strain has been deposited in the Spanish Type Culture Collection under the accession number CECT 7210. This novel strain has the main properties required of a probiotic, such as resistance to gastrointestinal juices, biliary salts, NaCl, and low pH, as well as adhesion to intestinal mucus and sensitivity to antibiotics. The food safety status has been confirmed by the absence of undesirable metabolite production and in acute ingestion studies of mice. Overall, these results demonstrate that Bifidobacterium longum subsp. infantis CECT 7210 can be considered a probiotic able to inhibit rotavirus infection.

  • Copyright © 2011, American Society for Microbiology. All Rights Reserved.
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Novel Probiotic Bifidobacterium longum subsp. infantis CECT 7210 Strain Active against Rotavirus Infections
José Antonio Moreno Muñoz, Empar Chenoll, Beatriz Casinos, Esther Bataller, Daniel Ramón, Salvador Genovés, Rebeca Montava, Juan Manuel Ribes, Javier Buesa, Joan Fàbrega, Montserrat Rivero
Appl. Environ. Microbiol. Dec 2011, 77 (24) 8775-8783; DOI: 10.1128/AEM.05548-11

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Novel Probiotic Bifidobacterium longum subsp. infantis CECT 7210 Strain Active against Rotavirus Infections
José Antonio Moreno Muñoz, Empar Chenoll, Beatriz Casinos, Esther Bataller, Daniel Ramón, Salvador Genovés, Rebeca Montava, Juan Manuel Ribes, Javier Buesa, Joan Fàbrega, Montserrat Rivero
Appl. Environ. Microbiol. Dec 2011, 77 (24) 8775-8783; DOI: 10.1128/AEM.05548-11
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