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Physiology

Polyphenolic Extract from Maple Syrup Potentiates Antibiotic Susceptibility and Reduces Biofilm Formation of Pathogenic Bacteria

Vimal B. Maisuria, Zeinab Hosseinidoust, Nathalie Tufenkji
M. J. Pettinari, Editor
Vimal B. Maisuria
Department of Chemical Engineering, McGill University, Montreal, Quebec, Canada
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Zeinab Hosseinidoust
Department of Chemical Engineering, McGill University, Montreal, Quebec, Canada
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Nathalie Tufenkji
Department of Chemical Engineering, McGill University, Montreal, Quebec, Canada
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M. J. Pettinari
Roles: Editor
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DOI: 10.1128/AEM.00239-15
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This article has a correction. Please see:

  • Correction for Maisuria et al., “Polyphenolic Extract from Maple Syrup Potentiates Antibiotic Susceptibility and Reduces Biofilm Formation of Pathogenic Bacteria” - July 20, 2020

ABSTRACT

Phenolic compounds are believed to be promising candidates as complementary therapeutics. Maple syrup, prepared by concentrating the sap from the North American maple tree, is a rich source of natural and process-derived phenolic compounds. In this work, we report the antimicrobial activity of a phenolic-rich maple syrup extract (PRMSE). PRMSE exhibited antimicrobial activity as well as strong synergistic interaction with selected antibiotics against Gram-negative clinical strains of Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa. Among the phenolic constituents of PRMSE, catechol exhibited strong synergy with antibiotics as well as with other phenolic components of PRMSE against bacterial growth. At sublethal concentrations, PRMSE and catechol efficiently reduced biofilm formation and increased the susceptibility of bacterial biofilms to antibiotics. In an effort to elucidate the mechanism for the observed synergy with antibiotics, PRMSE was found to increase outer membrane permeability of all bacterial strains and effectively inhibit efflux pump activity. Furthermore, transcriptome analysis revealed that PRMSE significantly repressed multiple-drug resistance genes as well as genes associated with motility, adhesion, biofilm formation, and virulence. Overall, this study provides a proof of concept and starting point for investigating the molecular mechanism of the reported increase in bacterial antibiotic susceptibility in the presence of PRMSE.

FOOTNOTES

    • Received 25 January 2015.
    • Accepted 23 March 2015.
    • Accepted manuscript posted online 27 March 2015.
  • Supplemental material for this article may be found at http://dx.doi.org/10.1128/AEM.00239-15.

  • Copyright © 2015, American Society for Microbiology. All Rights Reserved.
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Polyphenolic Extract from Maple Syrup Potentiates Antibiotic Susceptibility and Reduces Biofilm Formation of Pathogenic Bacteria
Vimal B. Maisuria, Zeinab Hosseinidoust, Nathalie Tufenkji
Applied and Environmental Microbiology May 2015, 81 (11) 3782-3792; DOI: 10.1128/AEM.00239-15

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Polyphenolic Extract from Maple Syrup Potentiates Antibiotic Susceptibility and Reduces Biofilm Formation of Pathogenic Bacteria
Vimal B. Maisuria, Zeinab Hosseinidoust, Nathalie Tufenkji
Applied and Environmental Microbiology May 2015, 81 (11) 3782-3792; DOI: 10.1128/AEM.00239-15
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