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Microbial Ecology | Spotlight

Exploring Vertical Transmission of Bifidobacteria from Mother to Child

Christian Milani, Leonardo Mancabelli, Gabriele Andrea Lugli, Sabrina Duranti, Francesca Turroni, Chiara Ferrario, Marta Mangifesta, Alice Viappiani, Pamela Ferretti, Valentina Gorfer, Adrian Tett, Nicola Segata, Douwe van Sinderen, Marco Ventura
M. W. Griffiths, Editor
Christian Milani
aLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Leonardo Mancabelli
aLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Gabriele Andrea Lugli
aLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Sabrina Duranti
aLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Francesca Turroni
bAlimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland
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Chiara Ferrario
aLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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Marta Mangifesta
cGenProbio, Parma, Italy
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Alice Viappiani
cGenProbio, Parma, Italy
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Pamela Ferretti
dCentre for Integrative Biology, University of Trento, Trento, Italy
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Valentina Gorfer
eAzienda Provinciale per i Servizi Sanitari, Trento, Italy
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Adrian Tett
dCentre for Integrative Biology, University of Trento, Trento, Italy
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Nicola Segata
dCentre for Integrative Biology, University of Trento, Trento, Italy
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Douwe van Sinderen
bAlimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland
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Marco Ventura
aLaboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
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M. W. Griffiths
Roles: Editor
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DOI: 10.1128/AEM.02037-15
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ABSTRACT

Passage through the birth canal and consequent exposure to the mother's microbiota is considered to represent the initiating event for microbial colonization of the gastrointestinal tract of the newborn. However, a precise evaluation of such suspected vertical microbiota transmission has yet to be performed. Here, we evaluated the microbiomes of four sample sets, each consisting of a mother's fecal and milk samples and the corresponding infant's fecal sample, by means of amplicon-based profiling supported by shotgun metagenomics data for two key samples. Notably, targeted genome reconstruction from microbiome data revealed vertical transmission of a Bifidobacterium breve strain and a Bifidobacterium longum subsp. longum strain from mother to infant, a notion confirmed by strain isolation and genome sequencing. Furthermore, PCR analyses targeting unique genes from these two strains highlighted their persistence in the infant gut at 6 months. Thus, this study demonstrates the existence of specific bifidobacterial strains that are common to mother and child and thus indicative of vertical transmission and that are maintained in the infant for at least relatively short time spans.

FOOTNOTES

    • Received 22 June 2015.
    • Accepted 27 July 2015.
    • Accepted manuscript posted online 31 July 2015.
  • Supplemental material for this article may be found at http://dx.doi.org/10.1128/AEM.02037-15.

  • Copyright © 2015, American Society for Microbiology. All Rights Reserved.
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Exploring Vertical Transmission of Bifidobacteria from Mother to Child
Christian Milani, Leonardo Mancabelli, Gabriele Andrea Lugli, Sabrina Duranti, Francesca Turroni, Chiara Ferrario, Marta Mangifesta, Alice Viappiani, Pamela Ferretti, Valentina Gorfer, Adrian Tett, Nicola Segata, Douwe van Sinderen, Marco Ventura
Applied and Environmental Microbiology Sep 2015, 81 (20) 7078-7087; DOI: 10.1128/AEM.02037-15

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Exploring Vertical Transmission of Bifidobacteria from Mother to Child
Christian Milani, Leonardo Mancabelli, Gabriele Andrea Lugli, Sabrina Duranti, Francesca Turroni, Chiara Ferrario, Marta Mangifesta, Alice Viappiani, Pamela Ferretti, Valentina Gorfer, Adrian Tett, Nicola Segata, Douwe van Sinderen, Marco Ventura
Applied and Environmental Microbiology Sep 2015, 81 (20) 7078-7087; DOI: 10.1128/AEM.02037-15
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