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Diamine Biosynthesis: Research Progress and Application Prospects

Li Wang, Guohui Li, Yu Deng
Robert M. Kelly, Editor
Li Wang
aNational Engineering Laboratory for Cereal Fermentation Technology (NELCF), Jiangnan University, Wuxi, Jiangsu, China
bJiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi, Jiangsu, China
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Guohui Li
aNational Engineering Laboratory for Cereal Fermentation Technology (NELCF), Jiangnan University, Wuxi, Jiangsu, China
bJiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi, Jiangsu, China
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Yu Deng
aNational Engineering Laboratory for Cereal Fermentation Technology (NELCF), Jiangnan University, Wuxi, Jiangsu, China
bJiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi, Jiangsu, China
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Robert M. Kelly
North Carolina State University
Roles: Editor
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DOI: 10.1128/AEM.01972-20
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ABSTRACT

Diamines are important monomers for polyamide plastics; they include 1,3-diaminopropane, 1,4-diaminobutane, 1,5-diaminopentane, and 1,6-diaminohexane, among others. With increasing attention on environmental problems and green sustainable development, utilizing renewable raw materials for the synthesis of diamines is crucial for the establishment of a sustainable plastics industry. Recently, high-performance microbial factories, such as Escherichia coli and Corynebacterium glutamicum, have been widely used in the production of diamines. In particular, several synthetic pathways of 1,6-diaminohexane have been proposed based on glutamate or adipic acid. Here, we reviewed approaches for the biosynthesis of diamines, including metabolic engineering and biocatalysis, and the application of bio-based diamines in nylon materials. The related challenges and opportunities in the development of renewable bio-based diamines and nylon materials are also discussed.

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Diamine Biosynthesis: Research Progress and Application Prospects
Li Wang, Guohui Li, Yu Deng
Applied and Environmental Microbiology Nov 2020, 86 (23) e01972-20; DOI: 10.1128/AEM.01972-20

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Diamine Biosynthesis: Research Progress and Application Prospects
Li Wang, Guohui Li, Yu Deng
Applied and Environmental Microbiology Nov 2020, 86 (23) e01972-20; DOI: 10.1128/AEM.01972-20
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  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • THE NATURAL SYNTHETIC PATHWAYS OF DIAMINES IN MICROORGANISMS
    • BIOPRODUCTION OF 1,3-DIAMINOPROPANE BASED ON NATURAL PATHWAYS
    • VARIOUS STRATEGIES FOR THE BIOSYNTHESIS OF PUTRESCINE
    • METABOLIC ENGINEERING FOR IMPROVING THE PRODUCTIVITY OF 1,5-DIAMINOPENTANE
    • BIOSYNTHESIS OF 1,6-DIAMINOHEXANE
    • BIO-BASED DIAMINES FOR APPLICATION TO BIO-BASED NYLON MATERIALS
    • PROSPECTS
    • ACKNOWLEDGMENTS
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

diamines
biosynthesis
nylon
metabolic engineering

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