Table 5.

Effects of substitution mutations on average hydrophobicities and average hydrophobic moments of selected pediocin AcH sequence regionsa

SequenceMutationHydrophobicityHydrophobic moments (<μ>)
A21 to G37None (wild type)0.390.20
I25 to G37None (wild type)0.450.30
I26T0.340.21
M31T0.400.35
A34D0.340.36
G37E0.360.25
G37R0.220.24
I25 to H42None (wild type)0.220.30
I26T0.140.24
M31T0.180.34
A34D0.140.34
G37E0.150.27
G37R0.050.24
N41K0.180.31
H42L0.300.22
• a Values were calculated by the method of Eisenberg et al. (9). <μ> values are a measure of the amphipathicity of a sequence.