Table 1.

Mortality observed in mice after intranasal instillation of different N. fowleri strainsa

StrainIsolation (day/mo/yr)Initial N. fowlericoncn in water (NPP/liter)Dose/mouseNo. of miceMortality (%)MTDb ± SD
D98.2.1.h1014/05/9887147,600201006.9 ± 0.71
D98.1.3.f13 05/03/98 95 34,000 13 100 5.3 ± 0.75
G98.1.1.h1 12/03/98 440 24,000 9 100 5.4 ± 0.52
G98.1.2.e23 12/03/98 34 20,000 11 100 5.3 ± 0.46
G98.2.3.f8a 06/05/98 588 14,700 10 100 5.2 ± 0.42
D98.2.1.h10 14/05/98 871 13,300 10 100 5.9 ± 0.56
S-L98.2.1.e10a 08/09/98 46.5 7,500 10 100 7.5 ± 0.97
Chi98.2.1.d8a 08/09/98 45.6 5,500 10 100 76 ± 1.26
Cat98.1.2.d6b 24/08/98 0.5 5,500 10 100 9.4 ± 1.26
D98.2.1.h1014/05/988714,5702010011.7 ± 5.56
S-L98.2.1.f1708/09/9846.53,400201007.6 ± 1.04
S-L98.2.1.f17 08/09/98 46.5 1,930 10 90 7.55 ± 1.42
D98.2.1.h1014/05/98871550207016.3 ± 7.36
S-L98.2.1.f1708/09/9846.537020859.3 ± 2.03
S-L98.2.1.f1708/09/9846.570203011.5 ± 2.26
  • a Italics indicate initial experiments effected without successive dilutions.

  • b MTD, mean time to death (in days).