TABLE 1.

Genetic loci that are regulated/putatively regulated by SigB and that may contribute to the tolerance of antimicrobial agents

Genetic locusaFunction/putative function
Cell wall related
    lmo2591cN-Acetylmuramidase
    lmo2691cAutolysin
    lmo2558cAutolysin (ami)
    lmo1076cAutolysin
    lmo0971-lmo0974c (dlt operon)d-Alanine transfer in lipoteichoic acids
    lmo2229cPenicillin binding protein
    lmo2754cPenicillin binding protein
    lmo0129dAutolysin
    murDdUDP-N-acetylmuramoylalanine d-glutamate ligase
    lmo2358dN-Acetylglucosamine-6-phosphate isomerase
    lmo2427dCell division protein
    lmo2504dCell wall binding protein
    eutCdEthanolamine ammonia lyase
    lmo0781bMannose-specific PTS componente
    mecAb (lmo2190)Competence negative regulator
    sepAbMetallo-beta-lactamase superfamily protein
    lmo0956bN-Acetylglucosamine-6-phosphate deacetylase
Efflux pumps
    lmo1300bEfflux pump
    lmo1409dEfflux pump (MdrL)
    lmo2463bEfflux pump
    lmo0605bEfflux pump
    lmo1226bEfflux pump
Stress
    lmo0222dMolecular chaperone (HtrO)
    lmo0292bMolecular chaperone (HtrA)
    lmo1860dPeptidyl methionine sulfoxide reductase
  • a Numbers refer to the National Center for Biotechnology Information (NCBI) annotation numbers.

  • b Previously shown to be positively regulated by SigB.

  • c Previously shown to be negatively regulated by SigB.

  • d A consensus SigB promoter was identified using the L. monocytogenes EGDe genome web server Listilist (http://genolist.pasteur.fr/ListiList/), suggesting that these genes may be regulated by SigB.

  • e PTS, phosphotransferase system.