TABLE 2.

Genes required for peroxisome organization and biogenesis identified in this study as determinants of yeast resistance to inhibitory ethanol concentrationsa

Gene/ORF nameProtein description
PEX1AAA family ATPase peroxin required for peroxisome biogenesis
PEX10RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import
PEX12RING finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import
PEX14Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery
PEX19Chaperone and import receptor for newly synthesized class I peroxisomal membrane proteins
PEX2RING finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain
PEX22Putative peroxisomal membrane protein required for import of peroxisomal proteins
PEX3Peroxisomal membrane protein required to recruit Pex19p chaperone to peroxisomes
PEX4Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
PEX5Peroxisomal membrane signal receptor for C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins
PEX8Intraperoxisomal organizer of the peroxisomal import machinery