TABLE 5.

Genes involved in cell wall biosynthesis identified in this study as determinants of yeast resistance to inhibitory ethanol concentrationsa

Gene/ORF nameProtein description
ANP1Subunit of the α-1,6-mannosyltransferase complex; type II membrane protein; involved in osmotic sensitivity
HOC1α-1,6-Mannosyltransferase involved in cell wall mannan biosynthesis
KRE6Protein required for β-1,6-glucan biosynthesis; putative β-glucan synthase
MNN10Subunit of a Golgi mannosyltransferase complex, also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p, that mediates elongation of the polysaccharide mannan backbone
SLG1Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity
SLT2Serine/threonine mitogen-activated protein kinase involved in regulating the maintenance of cell wall integrity; regulated by PKC1-mediated signaling pathway