TABLE 1.

Inhibition of bacterial physiology

ParameterPQ concnaActivity normalized to controlb
Respirationc10 nM111
25 nM106
50 nM106
75 nM20
100 nM11
Protein synthesis10 nM91
100 nM106
1 μM105
10 μM63
100 μM30
1 mM8
DNA synthesis10 nM109
100 nM98
1 μM102
10 μM56
100 μM15
1 mM4
  • a Ethanol controls had values similar to the control values.

  • b The control values were defined as 100.

  • c Respiration was also tested by using PQ concentrations up to 25 μM, and the levels of inhibition were similar to the level of inhibition observed with 100 nM.