TABLE 4.

Genes downregulated in excess copper

Locus tagGeneDescriptionFold change
Transport genes
    SAV0990 oppA Oligopeptide transporter binding protein−2.16
    SAV2316 potE Transport protein−2.13
    SAV0950 mnhC Putative monovalent cation/H+ antiporter subunit C−2.1
    SAS2358 opp-1A Oligopeptide transporter binding protein−2.09
Regulator genes
    SACOL2024 agrD Accessory gene regulator protein D−2.17
    SACOL0765 saeS Sensor histidine kinase SaeS−2.00
    SACOL0766 saeR Response regulator SaeR−2.01
Cofactor and carrier biosynthetic genes
    SAV1769 ribA Riboflavin biosynthesis−2.48
    SACOL0538 ispE 4-Diphosphocytidyl-2C-methyl-d-erythritol kinase−2.21
    SAV1771 ribD Riboflavin-specific deaminase−2.11
    SACOL1819 ribE Riboflavin synthase, alpha subunit−2.00
Protein biosynthesis genes
    SACOL059030S ribosomal protein L7−2.09
    SACOL0591 rpsL Ribosomal protein S12−2.25
    SACOL0592 rpsG Ribosomal protein S7−2.36
    SACOL0593 fusA Translation elongation factor−2.29
    SACOL2212 rplQ Ribosomal protein L17−2.17
    SACOL2213 rpoA DNA-directed RNA polymerase−2.27
    SACOL2216 rpmJ Ribosomal protein L36−2.75
    SACOL2217 infA Translation initiation factor IF-1−2.18
    SACOL2220 rplO Ribosomal protein L15−2.02
    SACOL2224 rplF Ribosomal protein L6−2.18
    SACOL2225 rpsH Ribosomal protein S8−2.19
    SACOL2226 rpsN2 Ribosomal protein S14−2.33
    SACOL2227 rplE Ribosomal protein L5−2.65
    SACOL2228 rplX Ribosomal protein L24−3.09
    SACOL2229 rplN Ribosomal protein L2−2.14
    SAV2247 rplB Ribosomal protein L36−2.75
    SACOL2234 rplV Ribosomal protein L22−2.09
    SACOL2235 rpsS Ribosomal protein S19−2.17
    SACOL2238 rplD Ribosomal protein L4−2.24
    SACOL2239 rplC Ribosomal protein L3−2.75