TABLE 3.

Genes upregulated in excess copper

Locus tagGeneaDescriptionFold change
Direct copper homeostasis mechanism genes
    SACOL2573 copZ Copper ion binding protein6.8
    SAV2557 copA Copper-transporting ATPase6.64
    SAS2591NADNA binding protein2.24
    SAS1326 phoU Putative phosphate transport system protein2.22
    SAS1804NAPutative exported protein2.1
Oxidative stress resistance genes
    SAV1713NAProbable thiol peroxidase2.77
    SAS2042 mrgA Putative non-heme-containing ferritin2.71
    SAS0357 ahpF Alkyl hydroperoxide reductase subunit F2.68
    SAR0135 sodM Superoxide dismutase2.56
    SACOL1155 trxA Thioredoxin2.42
    SAV0764 trxB Thioredoxin reductase2.20
    SAV2187NAQuinine oxidoreductase2.14
Misfolded protein response genes
    SACOL0570 clpC ClpC ATPase3.25
    SACOL0833 clpP ATP-dependent ClpP protease2.58
    SAV0975 clpB ClpB chaperone2.13
    SAS0479 ctsR CtsR transcriptional repressor2.44
  • a NA, not applicable.