TABLE 1.

Ethanol productivity of Corynebacterium glutamicum strain R-ldhA-pCRA723 and other organisms in the presence of inhibitors

InhibitorConcn (mM)OrganismEthanol productivitySubstrate (mM)eReference
Relative rate (%)Concn [mmol liter−1 h−1 (g liter−1 h−1)]
Furfural52Corynebacterium glutamicum strain R-ldhA-pCRA7238258 (2.7)Glu (200)This study
52Saccharomyces cerevisiae CBS 8066a4735 (1.6)Glu (167)22
47Escherichia coli ATCC 11303b61.1 (0.05)Xyl (533)1
5-HMF79C. glutamicum strain R-ldhA-pCRA7236243 (2.0)Glu (200)This study
60S. cerevisiae CEN.PKc365.6 (0.26)Glu (139)16
60S. cerevisiae TMB 3400c183.0 (0.14)Glu (139)16
4-HB16C. glutamicum strain R-ldhA-pCRA72310177 (3.6)Glu (200)This study
10S. cerevisiae ATCC 96581d3630 (1.4)Glu (167)12
Vanillin13C. glutamicum strain R-ldhA-pCRA7239869 (3.2)Glu (200)This study
10S. cerevisiae ATCC 96581d5843 (2.0)Glu (167)12
Syringaldehyde11C. glutamicum strain R-ldhA-pCRA7239371 (3.3)Glu (200)This study
10S. cerevisiae ATCC 96581d6956 (2.6)Glu (167)12
  • a First batch operation under anaerobic conditions in a conical flask containing 100 ml mineral salts medium and calcium alginate beads. The initial dry cell concentration was about 5 g liter−1 (30°C, pH 5.0).

  • b Batch operation under oxygen-limited conditions in a fermentor containing 350 ml complex medium. The initial dry cell concentration was 0.33 g liter−1 (30°C, pH 6.8).

  • c Batch operation under oxygen-limited conditions in glass vessels containing 22 ml mineral salts medium. The initial dry cell concentration was about 0.2 g liter−1 (30°C, pH 5.5).

  • d Batch operation in a stirred flask containing 40 ml mineral salts medium. The initial dry cell concentration was 2 g liter−1 (30°C, pH 5.0 to 5.5).

  • e Glu, glucose; Xyl, xylose.