TABLE 2

Approved β-lactam/β-lactamase inhibitor combinations

β-Lactam/β-lactamase inhibitor combinationYr introduced into clinical useRoute of administrationDosage regimenReference
Amoxicillin-clavulanate1981Oral20–40 mg/kg/day148
Ticarcillin-clavulanate1985Intravenous80 mg/kg every 6–8 h149
Ampicillin-sulbactam1997Intravenous100–200 mg/kg/day149
Cefoperazone-sulbactamIntravenous50–100 mg/kg/day150
Piperacillin-tazobactam1993Intravenous150–400 mg/kg/day151
Ceftolozane-tazobactam2014Intravenous1 g/0.5 g every 8 h152
Ceftazidime-avibactam2015Intravenous2.5-g infusion in 2 h every 8 h153