TABLE 1

Colonization and cariogenicity of S. mutans wild type and smu_833 mutant in ratsa

GroupMean ± SEM caries score by location and severitybS. mutans (CFU/ml [× 106])c
BuccalSulcalProximal
EDSDMDXEDSDMDXEDS
UA15913.0 ± 0.79.4 ± 0.77.4 ± 0.55.0 ± 0.520.2 ± 0.915.0 ± 0.38.6 ± 0.54.4 ± 0.45.2 ± 0.82.8 ± 0.511.0 ± 0.3
smu_833 mutant8.8 ± 0.76.2 ± 0.44.4 ± 0.61.8 ± 0.416.2 ± 0.411.2 ± 0.24.8 ± 0.61.2 ± 0.52.8 ± 0.80 ± 04.3 ± 0.6
Statistical significance********************NS******
  • a n = 5 per group. Weights (g): wild type, 136 ± 11; smu_833 mutant, 128 ± 10. There was no significant difference between the weights of the groups. **, P < 0.01; ***, P < 0.001; NS, no significance.

  • b E, enamel; DS, dentinal slight; DM, dentinal moderate; DX, dentinal extensive.

  • c Values were determined by plating plaque samples on mitis salivarius (MS) agar.