TABLE 2

Unique metabolic properties of the SAG genomes

Organism and functionaFunction IDTop BLAST matchb
PRT Nitrosopumilus
    FOG: PAS/PAC domaincCOG2202Signal transduction histidine kinase, with PAS, phosphoacceptor, and ATP binding domain (“Candidatus Nitrososphaera gargensis”)
    NhaD-type sodium/proton antiportersCOG1055Putative arsenical pump membrane protein (Nitrososphaera viennensis EN76)
    Lipoate-protein ligaseCOG0095Lipoate-protein ligase A (Aciduliprofundum sp. strain MAR08-339)
    Lipoate synthaseCOG0320Lipoyl synthase (Corallococcus coralloides)
    Glycine cleavage system H proteinCOG0509Glycine cleavage system protein H (Dictyoglomus thermophilum)
    Glycine dehydrogenase subunit 1COG0403Glycine dehydrogenase subunit 1 (Chloroherpeton thalassium)
    Glycine dehydrogenase subunit 2COG1003Glycine dehydrogenase subunit 2 (Carboxydothermus hydrogenoformans)
    AminomethyltransferaseCOG0404Glycine cleavage system protein T (Kosmotoga olearia)
    Dihydrolipoamide dehydrogenaseCOG1249Dihydrolipoamide dehydrogenase (Thermotoga lettingae)
    Urease subunit gammaCOG0831Urease subunit gamma (Nitrosopumilus sp. strain AR)
    Urease accessory proteinCOG2371Urease accessory protein (Cenarchaeum symbiosum)
    Urease accessory proteinCOG0830Urease accessory protein (C. symbiosum)
    Urease accessory proteinCOG0378Urease accessory protein UreG (C. symbiosum)
    Urease accessory proteinCOG0829Urease accessory protein UreD (“Candidatus Nitrososphaera gargensis”)
    Urease subunit alphaCOG0804Urease subunit alpha (C. symbiosum)
    Urease subunit betaCOG0832Urease subunit beta (N. viennensis EN76)
    Nitrogen regulatory protein P-II 2KO:K04752Hypothetical protein (“Candidatus Nitrosoarchaeum limnia”)
    UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferaseCOG1044Acetyltransferase (“Candidatus Nitrosopumilus salaria”)
    3-Oxoacyl-[acyl-carrier-protein] synthase IIICOG03323-Oxoacyl-ACP synthase (Microcystis aeruginosa)
    Aquaporin-4COG0580Glycerol transporter (“Candidatus Nitrosoarchaeum limnia”)
PRT SAR11
    6-PhosphofructokinaseCOG02056-Phosphofructokinase (alphaproteobacterium HIMB59)
    Pyruvate kinaseCOG0469Pyruvate kinase (Hydrogenivirga sp. strain 128-5-R1-1)
    Taurine dioxygenaseCOG2175Taurine catabolism dioxygenase TauD (“Candidatus Pelagibacter sp.” strain HTCC7211)
    TRAP-type C4-dicarboxylate transport system, large permease componentCOG1593TRAP transporter, DctM subunit (Clostridium bolteae)
    TRAP-type C4-dicarboxylate transport system, periplasmic componentCOG1638DctP family TRAP transporter solute receptor (C. bolteae)
    TRAP-type C4-dicarboxylate transport system, small permease componentCOG3090C4-dicarboxylate ABC transporter permease (Thermosinus carboxydivorans)
    TRAP-type uncharacterized transport system, periplasmic componentCOG2358C4-dicarboxylate ABC transporter substrate-binding protein (alphaproteobacterium HIMB114)
    TRAP-type uncharacterized transport system, fused permease componentsCOG4666C4-dicarboxylate ABC transporter (alphaproteobacterium HIMB114)
    ABC-type Mn/Zn transport systems, ATPase componentCOG1121Zinc transporter (alphaproteobacterium HIMB5)
    ABC-type sugar transport system, ATPase componentCOG1129Sugar ABC transporter ATP-binding protein (Rhizobium sp. strain CF142)
    Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease componentsCOG1172Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components (“Candidatus Pelagibacter ubique” HIMB058)
    ABC-type sugar transport system, periplasmic componentCOG1879LacI family transcriptional regulator (Kiloniella laminariae)
    ABC-type Zn2+ transport system, periplasmic component/surface adhesinCOG4531Zinc transporter (“Candidatus Pelagibacter sp.” HTCC7211)
    Maltose/maltodextrin transport system ATP-binding proteinCOG3839Sugar ABC transporter ATP-binding protein (Rhizobium sp. CF142)
    Na+/melibiose symporter and related transportersCOG2211Symporter (alphaproteobacterium HIMB59)
    3-Oxoacyl-[acyl-carrier-protein] synthase IIICOG0332Hypothetical protein (Mariprofundus ferrooxydans)
PRT Marinosulfonomonas
    Taurine dioxygenaseCOG2175Gamma-butyrobetaine dioxygenase (Labrenzia sp. strain DG1229)
    Aquaporin ZCOG0580Aquaporin (Rhodobacter sphaeroides)
    Thiamine monophosphate synthaseCOG0352Thiamine-phosphate pyrophosphorylase (Ahrensia sp. strain 13_GOM-1096 m)
    Thiamine biosynthesis protein, ThiCCOG0422Phosphomethylpyrimidine synthase (Pseudovibrio sp. strain FO-BEG1)
    Membrane-associated lipoprotein involved in thiamine biosynthesisCOG1477Thiamine biosynthesis protein ApbE (Pannonibacter phragmitetus)
    Hydroxymethylpyrimidine/phosphomethylpyrimidine kinaseCOG0351Hydroxymethylpyrimidine kinase (Sulfitobacter sp. strain MM-124)
    Thiamine biosynthesis, ThiGKO:K03149Thiazole synthase (Sulfitobacter sp. MM-124)
    Biotin synthase and related enzymesCOG0502Biotin synthase (Ruegeria sp. strain R11)
    Dethiobiotin synthetaseCOG0132Dethiobiotin synthetase (Phaeobacter gallaeciensis)
    Cobalamin biosynthesis protein, CbiGCOG2073Precorrin-3B methylase (Roseobacter sp. strain AzwK-3b)
    Nitrous oxide reductaseCOG4263Nitrous oxide reductase (Ruegeria lacuscaerulensis)
    Regulator of nitric oxide reductase transcriptionCOG3901FMN-binding protein (Roseobacter sp. strain SK209-2-6)
    Collagenase U32COG0826Peptidase U32 (Phaeobacter arcticus)
    Co/Zn/Cd cationsCOG0053ABC transporter permease (Rhodobacter sp. strain SW2)
    Na+/H+ antiportCOG2111Cation:proton antiporter (Rhodobacteraceae bacterium HTCC2150)
    ABC-type transporters for many drugsCOG0842ABC-type multidrug transport system, permease component (Thalassobacter arenae)
    ABC-type transporters for dipeptide/oligopeptide/nickelCOG1124Oligopeptide transport ATP-binding protein OppF (T. arenae)
    ABC-type transporters for long-chain fatty acidsCOG1133Transporter (“Candidatus Pelagibacter sp.” HTCC7211)
    ABC-type transporters for 2-aminoethylphosphonateCOG1178Iron ABC transporter permease (Labrenzia sp. DG1229)
PRT Psychromonas
    [NiFe]-hydrogenase I small subunitCOG1740Quinone-reactive [NiFe]-hydrogenase small chain (Shewanella halifaxensis)
    [NiFe]-hydrogenase I large subunitCOG0374Hydrogenase 2 large subunit (Shewanella frigidimarina)
    [NiFe]-hydrogenase I cytochrome b subunitCOG1969Hydrogenase (Shewanella loihica)
    Nitrate reductase cytochrome c-type subunit, NapBCOG3043Nitrate reductase (Psychromonas sp. CNPT3)
    Periplasmic nitrate reductase chaperone, NapDCOG3062Sorbose reductase (Psychromonas sp. CNPT3)
    Periplasmic nitrate reductase maturation protein NapFCOG1149Ferredoxin (Psychromonas sp. CNPT3)
    Trimethylamine N-oxide reductase system, NapECOG4459TorE protein (Psychromonas sp. CNPT3)
    ABC-type multidrug transport system, permease componentCOG0842ABC transporter (Psychromonas sp. CNPT3)
    Chemotaxis signal transduction proteinCOG0835Nitrate/nitrite sensor protein NarQ (Psychromonas sp. CNPT3)
  • a Metabolic potential is listed as novel when it is not found in the most closely related genome (MCRG).

  • b ACP, acyl carrier protein; FMN, flavin mononucleotide; ABC, ATP binding cassette; TRAP, tripartite ATP-independent periplasmic; UDP, uridine-diphosphate.

  • c Regulatory domains involved in signaling pathways.