Table 1.

Reactor dimensions, test conditions, and results

Reactor length (m) and sampleTemp (°C)Flow rate (ml/min)Residence time (s)Endotoxin concn (EU/ml)Endotoxin remaining (%)Note
TotalEndotoxin
0.61
    SDD-03-0127030.00.00.330.0713Water
    SDD-03-0227030.30.30.320.2885.1Endotoxin
    SDD-03-0327040.40.40.240.4748.4Endotoxin
    SDD-03-0424030.30.30.320.4688.3Endotoxin
    SDD-03-0524020.20.20.491.5828.1Endotoxin
    SDD-03-06Ambient30.00.00.336.94Water
    SDD-03-07Ambient20.20.20.495.63100.0Endotoxin
NA
    SDD-03-08AmbientNAaNANA549,750NASource vial
0.61
    SDD-03-09Ambient30.00.0NA0.25NAWater
    SDD-03-10Ambient30.00.6NA1,300NAEndotoxin
    SDD-03-11Ambient30.00.6NA2,500NAEndotoxin
    SDD-03-12Ambient30.00.6NA2,500NAEndotoxin
    SDD-03-13Ambient30.00.6NA2,500NAEndotoxin, TEA
    SDD-03-14Ambient30.00.0NA100 & 100bNATEA
NA
    SDD-03-15Ambient0.00.0NA3,500NAFeed source
1.22
    SDD-03-1625020.00.00.940.0230.001Water
    SDD-03-1725020.00.40.940.2760.007Endotoxin
    SDD-03-1825020.00.40.940.8520.021Endotoxin
    SDD-03-1925040.00.80.4732.90.823Endotoxin
    SDD-03-2025060.01.20.311293.225Endotoxin
    SDD-03-2125060.01.20.311313.275Endotoxin
    SDD-03-22Ambient40.00.8NA1,560*cFeed source
3.66
    SDD-03-2327030.00.01.88<0.0100.0002Water
    SDD-03-2427030.00.61.880.01700.0004Endotoxin
    SDD-03-2527040.00.81.410.10600.0026Endotoxin
    SDD-03-2627050.01.01.130.04800.0012Endotoxin
    SDD-03-2725020.00.42.810.0080.0002Endotoxin
    SDD-03-2825030.00.61.880.0120.0003Endotoxin
    SDD-03-2925040.00.81.410.0330.0008Endotoxin
    SDD-03-30Ambient20.00.4NA4,020100Feed source
    SDD-03-3123020.00.02.810.0700.0016Water
    SDD-03-3223020.00.42.816.140.14Endotoxin
    SDD-03-3323035.00.71.6122.60.52Endotoxin
    SDD-03-3423050.01.01.1346.61.07Endotoxin
    SDD-03-3521020.00.42.811493.4Endotoxin
    SDD-03-3621035.00.71.6186419.9Endotoxin
    SDD-03-3721050.01.01.1369916.1Endotoxin
    SDD-03-38Ambient20.00.4NA4,340100Feed source
  • a NA, not applicable.

  • b Repeat analysis of the same sample.

  • c A process upset caused the endotoxin concentration of sample SDD-03-22 to be artificially low. Since the endotoxin concentration in feed, ∼4,000 EU/ml, was confirmed using the same sample preparation procedure, this value was used to determine the percentage of endotoxin remaining.