Table 3.

Therapeutic effects of 3-day BCN L-1077 treatments, of various concentrations, against a mixed infection of Campylobacter jejuni and Salmonella Enteritidis 92 Rifr in 43-day-old broilersa

Chicken group (conditions)BroilerBCN dose (mg/bird)Log10 CFU/g organ homogenate (after treatment)
Lactic acid bacteria in cecal contentC. jejuniS. Enteritidis
LiverSpleenLiverSpleen
Control group (commercial feed; bacteriocin-free water)106.794.868.658.608.60
26.794.268.088.498.46
38.574.808.567.908.28
48.457.488.387.858.36
58.115.268.468.528.59
68.407.368.328.608.43
Avg (no. of birds averaged)7.85 (6)6.96 (6)8.45 (6)8.41 (6)8.46 (6)
Exptl group 1 (commercial feed; 25 mg bacteriocin L-1077/liter)721.38.15NDbNDND4.61
88.15ND4.154.23ND
98.76ND3.81NDND
107.56NDNDNDND
118.60NDNDNDND
127.30NDNDNDND
138.30ND2.76NDND
147.28ND2.60NDND
Avg (no. of birds averaged)8.28 (8)ND (8)ND (4), 2.69 (2), 3.81 (1), 4.15 (1)ND (7), 4.23 (1)ND (7), 4.61 (1)
Exptl group 2 (commercial feed and water with 12.5 mg BCN L-1077/liter)1510.98.46NDND3.43ND
167.60NDNDNDND
178.95NDNDNDND
188.81ND2.81NDND
198.04NDNDNDND
206.85NDNDNDND
217.77NDNDND1.95
228.08ND2.34NDND
Avg (no. of birds averaged)8.43 (8)ND (8)ND (6), 2.63 (2)ND (7), 3.43 (1)ND (7), 1.95 (1)
Exptl group 3 (commercial feed and water with 6.25 mg BCN L-1077/liter)235.57.30NDNDNDND
248.11NDNDNDND
258.69NDNDNDND
266.52ND3.08NDND
278.60ND4.114.234.28
289.26ND3.344.464.43
298.30ND3.384.324.23
307.83NDND4.324.15
Avg (no. of birds averaged)8.59 (8)ND (8)ND (4), 3.28 (3), 4.11 (1)ND (4), 4.34 (4)ND (4), 4.28 (4)
  • a All birds were commercially colonized with nonspecified C. jejuni.

  • b ND, none detected; detection limit of >100 cells.