Table 2

Distribution of annotated proteins associated with disinfectant and antibiotic resistance mechanisms

MechanismGene% of total in:P value
CHL waterCHM water
Disinfectant resistance
Glutathione protection
    Glutathione synthetasegshB0.0060.007NSb
    Glutathione reductasegorA0.0850.042<0.001
    Nonspecific DNA-binding proteindps0.0260.070<0.001
OxyR system
    Hydrogen peroxide-inducible regulatoroxyR0.0090.038<0.001
    Peroxidase/catalasekatG0.1340.152NS
    Alkyl hydroperoxide reductase proteinahpFNDa0.004NS
    Glutaredoxin reductasegrxA0.0130.015NS
    Thioredoxin reductasetrxB0.5820.095<0.001
SoxRS system
    Redox-sensitive transcriptional regulatorsoxR0.0010.004NS
    Manganese superoxide dismutasesodA0.019NDNS
RpoS regulated genes
    RNA polymerase sigma factorrpoS0.0120.004NS
    Cu-Zn superoxide dismutasesodC0.002NDNS
    Exo-DNase IIIxthA0.0800.074NS
EPS (biofilms)
    EPS transport protein0.0010.134<0.001
    Capsular EPS0.0130.195<0.001
Antibiotic resistance
    Beta-lactamasebla0.0760.130<0.01
    Sulfonamides, dihydropteroate synthasesul0.0140.006NS
    Tetracycline, small GTP-binding proteinc0.1190.065<0.01
Multidrug efflux pump and transporter
    Multidrug resistance protein (pumps)0.0400.114<0.01
    Small multidrug resistance proteinsmr0.0060.002NS
    RNDd family membrane fusion proteinmfp0.3230.145<0.001
    Multidrug efflux transportermexF0.0370.025NS
    RNDrnd0.4020.467NS
    Multidrug efflux pumpacrBDF1.8851.751NS
    Membrane proteinmarC0.0100.010NS
  • a ND, not detected.

  • b NS, not significant.

  • c Related to TetM.

  • d RND, resistance-nodulation-cell division.