TABLE 2

Effect of sialic acid on the transcriptome of B. breve UCC2003

Locus tag (gene)Predicted functionLevel of upregulationa
Bbr_0160Conserved hypothetical protein37.32
Bbr_0161 (nanK)Conserved hypothetical protein in ROK family59.01
Bbr_0162 (nanE)N-Acetylmannosamine-6-phosphate 2-epimerase49.91
Bbr_0163Hydrolase51.55
Bbr_0164 (nanB)Substrate-binding protein367.68
Bbr_0165 (nanC)ABC transport system permease protein451.08
Bbr_0166 (nanD)ABC transport system ATP-binding protein453.7
Bbr_0167 (nanF)ABC transport system ATP-binding protein435.43
Bbr_0168 (nanA)N-Acetylneuraminate lyase435.04
Bbr_0169 (nagB1)Glucosamine-6-phosphate isomerase275.38
Bbr_0171 (nanH)Sialidase A204.69
Bbr_0172ATPase6.7
Bbr_1247 (nagA2)N-Acetylglucosamine-6-phosphate deacetylase3.07
Bbr_1248 (nagB3)Glucosamine-6-phosphate isomerase4.11
  • a The cutoff point is 3-fold with a P value of <0.001.