TABLE 6

Comparison of transcriptomes of the S. pneumoniae D39 ΔlacR and D39 wild-type strains grown in GM17

D39 tagaFunctionbRatioc
SPD_0562β-Galactosidase4.9
SPD_1044Lactose phosphotransferase system repressor (LacR)−27.3
SPD_10466-Phospho-β-galactosidase (LacG)1.0
SPD_1047PTS system, lactose-specific IIBC components (LacE)1.6
SPD_1048PTS system, lactose-specific IIA component (LacF)−1.3
SPD_1049Transcription antiterminator (LacT)−2.0
SPD_1050Tagatose-1,6-diphosphate aldolase (LacD)18.5
SPD_1051Tagatose-6-phosphate kinase (LacC)10.5
SPD_1052Galactose-6-phosphate isomerase (LacB subunit)33.0
SPD_1053Galactose-6-phosphate isomerase (LacA subunit)15.5
  • a Gene numbers refer to D39 locus tags.

  • b D39 annotation/TIGR4 annotation (23, 25, 72).

  • c Ratio of the fold increase/decrease in the expression of genes in the ΔlacR strain compared to that in the wild type.