TABLE 1

Kinetic thermostability and activity in organic solventsa

ParameterPaDa-IVariant 16.5Variant 6.1Variant 7.1Variant 4.7
Thermostability t1/2 (min)8.74316.62.98.7
C50 (%)
    Acetonitrile7.07.217.58.820.3
    DMSO2.01.72.81.32.3
    Ethanol1.01.01.01.01.0
    Methanol8.48.89.67.89.7
    Acetone10.011.613.28.113.1
  • a Values were calculated from the t1/2 and C50 plots of Fig. S5 in the supplemental material.