TABLE 1

KEGG enrichment analysis of significant MGWA predictionsa

KEGG pathway IDbKEGG pathway nameNo. of top genescTotal no. of genesdP value
ko00860Porphyrin and chlorophyll metabolism14420.002
ko00900Terpenoid backbone biosynthesis8170.004
ko00780Biotin metabolism6100.004
ko02020Two-component system71570.01
ko01120Microbial metabolism in diverse environments202910.02
ko00270Cysteine and methionine metabolism11430.03
ko00480Glutathione metabolism5130.03
  • a Using a survival model that accounted for experimental block and the monoassociated bacterial strain as random effects, we detected the association between gene presence or absence for 13,343 clusters of orthologous groups (OGs) and D. melanogaster SR. KEGG enrichment analysis of OGs identified bacterial functions that were enriched in the MGWA predictions, resulting in the categories listed above. KEGG identification number and pathway type are identified on the left, with significant P values on the right. The genes listed in each category were among the top-ranked MGWA predictions; methionine metabolism is among these top hits.

  • b ID, identification.

  • c Number of KEGG pathway genes in the 432 most significant OGs.

  • d Number of KEGG pathway genes in all 13,343 clustered OGs.