TABLE 1

Details for species with high correlations with the three variablesf

Variable and no.aPhylumSpeciesHOTb
Positive
    pH
        S40BacteroidetesCapnocytophaga sp.332
        S269eBacteroidetesPrevotella multisaccharivorax794
        S227BacteroidetesPrevotella oralis705
        S45BacteroidetesAlloprevotella sp.912
        S382eFirmicutesStreptococcus sobrinus768
        S158FusobacteriaLeptotrichia buccalis563
        S1ProteobacteriaNeisseria subflava476
        S154ProteobacteriaCardiobacterium hominis633
        S237cProteobacteriaNeisseria lactamica649
        S344SpirochaetesTreponema sp.227
        S306TenericutesMycoplasma faucium606
    Iron
        S43BacteroidetesPrevotella sp.299
        S116BacteroidetesPrevotella veroralis572
        S194BacteroidetesCapnocytophaga sp.863
        S330eFirmicutesLachnoanaerobaculum sp.496
        S207FirmicutesMitsuokella sp.521
        S218FirmicutesMoryella sp.419
        S46FirmicutesStreptococcus constellatus576
        S60dFirmicutesStreptococcus sp.56
        S351ProteobacteriaDesulfovibrio sp.40
        S38SpirochaetesTreponema amylovorum541
        S123dSynergistetesFretibacterium fastidiosum363
    DMFT
        S183ActinobacteriaAtopobium rimae750
        S310eBacteroidetesCapnocytophaga sp.902
        S125BacteroidetesPrevotella shahii795
        S234dFirmicutesMegasphaera sp.123
        S181FirmicutesLachnospiraceae [G-2] sp.88
        S120dFirmicutesClostridiales [F-1][G-1] sp.93
        S109FirmicutesVeillonellaceae [G-1] sp.155
        S54SpirochaetesTreponema denticola584
        S352eTM7TM7 [G-4] sp.355
Negative
    pH
        S141BacteroidetesBacteroidetes [G-6] sp.516
        S98BacteroidetesBacteroidetes [G-5] sp.505
        S14BacteroidetesPorphyromonas endodontalis273
        S256BacteroidetesBacteroidetes [G-5] sp.511
        S51BacteroidetesPrevotella sp.526
        S108FirmicutesLachnospiraceae [G-3] sp.100
        S412FirmicutesEnterococcus saccharolyticus802
        S189FirmicutesPeptostreptococcaceae [XI][G-4] sp.369
        S149FirmicutesLactobacillus vaginalis51
        S387eFirmicutesEnterococcus durans880
        S241FusobacteriaLeptotrichia sp.218
        S203FusobacteriaFusobacterium sp.370
        S122FusobacteriaLeptotrichiaceae [G-1] sp.210
        S128ProteobacteriaHaemophilus parainfluenzae718
        S71SpirochaetesTreponema sp.235
        S200SpirochaetesTreponema sp.226
    Iron
        S408ActinobacteriaBifidobacterium dentium588
        S291ActinobacteriaOlsenella sp.807
        S69ActinobacteriaCorynebacterium matruchotii666
        S295ActinobacteriaActinomyces sp.897
        S276BacteroidetesPorphyromonas sp.275
        S68BacteroidetesFlavobacteriales [G-1] sp.318
        S40BacteroidetesCapnocytophaga sp.332
        S36BacteroidetesPrevotella denticola291
        S260FirmicutesEnterococcus italicus803
        S198FirmicutesPeptostreptococcaceae [XI][G-5] sp.493
        S375ProteobacteriaRalstonia sp.27
        S1ProteobacteriaNeisseria subflava476
  • a No. indicates the number of the species in the RDA plot (see Fig. S4); boldface font indicates a correlation of >0.996 (±5°).

  • b HOT indicates the human oral taxon ID in the Human Oral Microbiome Database (http://www.homd.org/index.php).

  • c Non-caries-associated species.

  • d Caries-associated species.

  • e Low-abundance species with a community-wide impact.

  • f Correlation value of >0.985 (±10°) (Fig. 5b).