antivirulence

  • A Tailspike with Exopolysaccharide Depolymerase Activity from a New <span class="named-content genus-species" id="named-content-1">Providencia stuartii</span> Phage Makes Multidrug-Resistant Bacteria Susceptible to Serum-Mediated Killing
    Biotechnology | Spotlight
    A Tailspike with Exopolysaccharide Depolymerase Activity from a New Providencia stuartii Phage Makes Multidrug-Resistant Bacteria Susceptible to Serum-Mediated Killing

    The pace at which multidrug-resistant strains emerge has been alarming. P. stuartii is an infrequent but relevant drug-resistant nosocomial pathogen causing local to systemic life-threatening infections. We propose an alternative approach to fight this bacterium based on the properties of phage tailspikes with depolymerase activity that degrade the surface bacterial...

    Hugo Oliveira, Graça Pinto, Bruna Mendes, Oscar Dias, Hanne Hendrix, Ergun Akturk, Jean-Paul Noben, Jan Gawor, Małgorzata Łobocka, Rob Lavigne, Joana Azeredo
  • Small Molecules Produced by Commensal <span class="named-content genus-species" id="named-content-1">Staphylococcus epidermidis</span> Disrupt Formation of Biofilms by <span class="named-content genus-species" id="named-content-2">Staphylococcus aureus</span>
    Environmental Microbiology | Spotlight
    Small Molecules Produced by Commensal Staphylococcus epidermidis Disrupt Formation of Biofilms by Staphylococcus aureus

    S. aureus is a leading agent of infections worldwide, and its main virulence characteristic is the ability to produce biofilms on surfaces such as medical devices. Biofilms are known to confer increased resistance to antimicrobials and to the host immune responses, requiring aggressive antibiotic treatment and removal of the infected surface. Here, we investigated a...

    Thaís Glatthardt, Juliana Curityba de Mello Campos, Raiane Cardoso Chamon, Thiago Freitas de Sá Coimbra, Giulia de Almeida Rocha, Marília Alves Figueira de Melo, Thiago Estevam Parente, Leandro Araujo Lobo, Luis Caetano Martha Antunes, Kátia Regina Netto dos Santos, Rosana Barreto Rocha Ferreira
  • K2 Capsule Depolymerase Is Highly Stable, Is Refractory to Resistance, and Protects Larvae and Mice from <span class="named-content genus-species" id="named-content-1">Acinetobacter baumannii</span> Sepsis
    Public and Environmental Health Microbiology | Spotlight
    K2 Capsule Depolymerase Is Highly Stable, Is Refractory to Resistance, and Protects Larvae and Mice from Acinetobacter baumannii Sepsis

    Acinetobacter baumannii is an important nosocomial pathogen resistant to many, and sometimes all, antibiotics. The A. baumannii K2 capsular type has been associated with elevated antibiotic resistance. The capsular depolymerase characterized here fits the new trend of alternative antibacterial...

    Hugo Oliveira, Ana Mendes, Alexandra G. Fraga, Alice Ferreira, Andreia I. Pimenta, Dalila Mil-Homens, Arsénio M. Fialho, Jorge Pedrosa, Joana Azeredo
  • Amentoflavone Ameliorates <span class="named-content genus-species" id="named-content-1">Streptococcus suis</span>-Induced Infection <em>In Vitro</em> and <em>In Vivo</em>
    Public and Environmental Health Microbiology
    Amentoflavone Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo

    The widespread use of antibiotics in therapy and in the prevention of Streptococcus suis infection in the swine industry raises concerns for the emergence of a resistant strain. The use of antivirulence agents has potential benefits, mainly because of the reduced selective pressure for the development of bacterial resistance. In this study, we found that amentoflavone...

    Xue Shen, Xiaodi Niu, Gen Li, Xuming Deng, Jianfeng Wang
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