DNA phosphorothioation
Enzymology and Protein Engineering | SpotlightPhosphorothioated DNA Is Shielded from Oxidative DamageDNA phosphorothioation has been reported in many bacteria. These PT-hosting bacteria live in very different environments, such as the human body, soil, or hot springs. The physiological function of DNA PT modification is still elusive. A remarkable property of PT modification is that purified genomic PT DNA is susceptible to oxidative cleavage. Among the oxidants, hypochlorous acid and H2O2 are of physiological...