fatty acyl-AMP ligase
- Genetics and Molecular BiologyAlternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides
Herein, we deciphered the most important biosynthetic traits of a prominent group of bioactive lipopeptides. We reveal evidence for initiation of biosynthesis by two alternative starter units hardwired directly in the same gene cluster, eventually resulting in the production of a remarkable range of lipopeptide variants. We identified several unusual tailoring genes potentially involved in modifying the fatty acid chain. Careful...