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Applied and Environmental Microbiology
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nonribosomal peptide synthetase

  • The ADEP Biosynthetic Gene Cluster in <span class="named-content genus-species" id="named-content-1">Streptomyces hawaiiensis</span> NRRL 15010 Reveals an Accessory <em>clpP</em> Gene as a Novel Antibiotic Resistance Factor
    Environmental Microbiology
    The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor

    Antibiotic acyldepsipeptides (ADEPs) represent a promising new class of potent antibiotics and, at the same time, are valuable tools to study the molecular functioning of their target, ClpP, the proteolytic core of the bacterial caseinolytic protease. Here, we present a straightforward purification procedure for ADEP1 that yields substantial amounts of the pure compound in a time- and cost-efficient manner, which is a prerequisite to...

    Dhana Thomy, Elizabeth Culp, Martina Adamek, Eric Y. Cheng, Nadine Ziemert, Gerard D. Wright, Peter Sass, Heike Brötz-Oesterhelt
  • Synthesis of <span class="sc">d</span>-Amino Acid-Containing Dipeptides Using the Adenylation Domains of Nonribosomal Peptide Synthetase
    Biotechnology
    Synthesis of d-Amino Acid-Containing Dipeptides Using the Adenylation Domains of Nonribosomal Peptide Synthetase

    Because almost all amino acids in nature are l-amino acids, the functioning of d-amino acids has received little attention. Thus, there is little information available on the activity of enzymes toward d-amino acids or synthetic methods for d-amino acid-containing dipeptides. Recently, d-amino acids and...

    Soichiro Kano, Shin Suzuki, Ryotaro Hara, Kuniki Kino
  • Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides
    Genetics and Molecular Biology
    Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides

    Herein, we deciphered the most important biosynthetic traits of a prominent group of bioactive lipopeptides. We reveal evidence for initiation of biosynthesis by two alternative starter units hardwired directly in the same gene cluster, eventually resulting in the production of a remarkable range of lipopeptide variants. We identified several unusual tailoring genes potentially involved in modifying the fatty acid chain. Careful...

    Jan Mareš, Jan Hájek, Petra Urajová, Andreja Kust, Jouni Jokela, Kumar Saurav, Tomáš Galica, Kateřina Čapková, Antti Mattila, Esa Haapaniemi, Perttu Permi, Ivar Mysterud, Olav M. Skulberg, Jan Karlsen, David P. Fewer, Kaarina Sivonen, Hanne Hjorth Tønnesen, Pavel Hrouzek
  • Enzymology and Protein Engineering | Spotlight
    A Highly Conserved Basidiomycete Peptide Synthetase Produces a Trimeric Hydroxamate Siderophore
    Eileen Brandenburger, Markus Gressler, Robin Leonhardt, Gerald Lackner, Andreas Habel, Christian Hertweck, Matthias Brock, Dirk Hoffmeister
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