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probiotic

  • Generation of Lactose- and Protease-Positive Probiotic <em>Lacticaseibacillus rhamnosus</em> GG by Conjugation with <em>Lactococcus lactis</em> NCDO 712
    Food Microbiology
    Generation of Lactose- and Protease-Positive Probiotic Lacticaseibacillus rhamnosus GG by Conjugation with Lactococcus lactis NCDO 712

    Probiotic strain Lacticaseibacillus rhamnosus GG (LGG) is widely sold on the market as a probiotic or added as a supplement in dairy foods because of its benefits in human health. However, due to the deficiency of lactose and casein utilization, LGG does not grow well in milk.

    Nazar Hussain, Ran Li, Timo M. Takala, Muhammad Tariq, Arsalan H. Zaidi, Per E. J. Saris
  • Portable CRISPR-Cas9<sup>N</sup> System for Flexible Genome Engineering in <span class="named-content genus-species" id="named-content-1">Lactobacillus acidophilus</span>, <span class="named-content genus-species" id="named-content-2">Lactobacillus gasseri</span>, and <span class="named-content genus-species" id="named-content-3">Lactobacillus paracasei</span>
    Methods
    Portable CRISPR-Cas9N System for Flexible Genome Engineering in Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus paracasei

    This work describes the development of a lactobacillus CRISPR-based editing system for genome manipulations in three Lactobacillus species belonging to the lactic acid bacteria (LAB), which are commonly known for their long history of use in food fermentations and as indigenous members of healthy microbiotas and for their emerging roles in human and animal commercial health-promoting applications. We exploited the established...

    Yong Jun Goh, Rodolphe Barrangou
  • Mucin as a Functional Niche Is a More Important Driver of <em>In Vitro</em> Gut Microbiota Composition and Functionality than <span class="named-content genus-species" id="named-content-1">Akkermansia muciniphila</span> Supplementation
    Microbial Ecology
    Mucin as a Functional Niche Is a More Important Driver of In Vitro Gut Microbiota Composition and Functionality than Akkermansia muciniphila Supplementation

    Research into the identification of biomarkers for gut health and ways to modulate the microbiota composition and activity to improve health has put Akkermansia muciniphila in the spotlight. As a mucin degrader, A. muciniphila colonizes the interesting but not fully described host-glycan degradation niche. Much of research concerning A. muciniphila...

    Florence Van Herreweghen, Kim De Paepe, Massimo Marzorati, Tom Van de Wiele
  • An 1,4-α-Glucosyltransferase Defines a New Maltodextrin Catabolism Scheme in <span class="named-content genus-species" id="named-content-1">Lactobacillus acidophilus</span>
    Enzymology and Protein Engineering
    An 1,4-α-Glucosyltransferase Defines a New Maltodextrin Catabolism Scheme in Lactobacillus acidophilus

    The degradation of starch in the small intestine generates short linear and branched α-glucans. The latter are poorly digestible by humans, rendering them available to the gut microbiota, e.g., lactobacilli adapted to the small intestine and considered beneficial to health. This study unveils a previously unknown scheme of maltooligosaccharide (MOS) catabolism via the concerted activity of an 1,4-α-glucosyltransferase together with a...

    Susan Andersen, Marie S. Møller, Jens-Christian N. Poulsen, Michael J. Pichler, Birte Svensson, Leila Lo Leggio, Yong Jun Goh, Maher Abou Hachem
  • Putative Adhesion Factors in Vaginal <span class="named-content genus-species" id="named-content-1">Lactobacillus gasseri</span> DSM 14869: Functional Characterization
    Genetics and Molecular Biology | Spotlight
    Putative Adhesion Factors in Vaginal Lactobacillus gasseri DSM 14869: Functional Characterization

    Lactobacilli are known to contribute to the maintenance of a healthy vaginal microbiota and some are selected as probiotics for the prevention or treatment of urogenital diseases, such as bacterial vaginosis. However, the molecular mechanisms for these health-promoting effects are not fully understood. Here, we functionally identified three cell surface factors of a ...

    Zhu Zeng, Fanglei Zuo, Harold Marcotte
  • An <em>In Vitro</em> Enrichment Strategy for Formulating Synergistic Synbiotics
    Microbial Ecology | Spotlight
    An In Vitro Enrichment Strategy for Formulating Synergistic Synbiotics

    This study describes an in vitro enrichment method to formulate synergistic synbiotics that have potential for establishing autochthonous strains across multiple individuals. The rationale for this approach—that the chance of survival of a bacterial strain is improved by providing it with its required resources—is based on classic ecological theory. From these experiments, a human-derived strain,...

    Car Reen Kok, David Fabian Gomez Quintero, Clement Niyirora, Devin Rose, Amanda Li, Robert Hutkins
  • Open Access
    Exploiting Prophage-Mediated Lysis for Biotherapeutic Release by <em>Lactobacillus reuteri</em>
    Meeting Presentation | Spotlight
    Exploiting Prophage-Mediated Lysis for Biotherapeutic Release by Lactobacillus reuteri

    Lactic acid bacteria (LAB) have been explored as potential biotherapeutic vehicles for the past 20 years. To secrete a therapeutic in the extracellular milieu, one typically relies on the bacterial secretion pathway, i.e., the Sec pathway. Overexpression of a secreted protein can overload the secretory pathway and impact the organism’s fitness, and optimization of the signal peptide is also required to maximize the efficiency of the...

    Laura M. Alexander, Jee-Hwan Oh, Donald S. Stapleton, Kathryn L. Schueler, Mark P. Keller, Alan D. Attie, Jan-Peter van Pijkeren
  • Open Access
    Gut Symbionts <span class="named-content genus-species" id="named-content-1">Lactobacillus reuteri</span> R2lc and 2010 Encode a Polyketide Synthase Cluster That Activates the Mammalian Aryl Hydrocarbon Receptor
    Meeting Presentation
    Gut Symbionts Lactobacillus reuteri R2lc and 2010 Encode a Polyketide Synthase Cluster That Activates the Mammalian Aryl Hydrocarbon Receptor

    Temporary changes in the composition of the microbiota, for example, by oral administration of probiotics, can modulate the host immune system. However, the underlying mechanisms by which probiotics interact with the host are often unknown. Here, we show that Lactobacillus reuteri R2lc and 2010 harbor an orthologous PKS gene cluster that activates the aryl hydrocarbon...

    Mustafa Özçam, Restituto Tocmo, Jee-Hwan Oh, Amin Afrazi, Joshua D. Mezrich, Stefan Roos, Jan Claesen, Jan-Peter van Pijkeren
  • Surface Layer of <em>Lactobacillus helveticus</em> MIMLh5 Promotes Endocytosis by Dendritic Cells
    Food Microbiology
    Surface Layer of Lactobacillus helveticus MIMLh5 Promotes Endocytosis by Dendritic Cells

    Beneficial microbes may positively affect host physiology at various levels, e.g., by participating in immune system maturation and modulation, boosting defenses and dampening reactions, thus affecting the whole homeostasis. As a consequence, the use of probiotics is increasingly regarded as suitable for more extended applications for health maintenance, not only microbiota balancing. This implies a deep knowledge of the mechanisms and...

    Valentina Taverniti, Mauro Marengo, Eva Fuglsang, Helene Marie Skovsted, Stefania Arioli, Giacomo Mantegazza, Giorgio Gargari, Stefania Iametti, Francesco Bonomi, Simone Guglielmetti, Hanne Frøkiær
  • Dissecting the Evolutionary Development of the Species <em>Bifidobacterium animalis</em> through Comparative Genomics Analyses
    Microbial Ecology
    Dissecting the Evolutionary Development of the Species Bifidobacterium animalis through Comparative Genomics Analyses

    The majority of characterized B. animalis strains have been isolated from human fecal samples. In order to explore genome variability within this species, we isolated 15 novel strains from the gastrointestinal tracts of different animals, including mammals and birds. The present study allowed us to reconstruct the pangenome of this taxon, including the genome contents...

    Gabriele Andrea Lugli, Walter Mancino, Christian Milani, Sabrina Duranti, Leonardo Mancabelli, Stefania Napoli, Marta Mangifesta, Alice Viappiani, Rosaria Anzalone, Giulia Longhi, Douwe van Sinderen, Marco Ventura, Francesca Turroni

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Print ISSN: 0099-2240; Online ISSN: 1098-5336