S. avermitilis
![SufR, a [4Fe-4S] Cluster-Containing Transcription Factor, Represses the <em>sufRBDCSU</em> Operon in <span class="named-content genus-species" id="named-content-1">Streptomyces avermitilis</span> Iron-Sulfur Cluster Assembly](https://aem.asm.org/sites/default/files/styles/thumbnail/public/externals/c933d14fbad97ae6fb2bb51eafd342e7.jpg?itok=K4ghBlP_)
Genetics and Molecular BiologySufR, a [4Fe-4S] Cluster-Containing Transcription Factor, Represses the sufRBDCSU Operon in Streptomyces avermitilis Iron-Sulfur Cluster AssemblyFe–S clusters function as cofactors of proteins controlling diverse biological processes, such as respiration, photosynthesis, nitrogen fixation, DNA replication, and gene regulation. The mechanism of how Actinobacteria regulate the expression of the sole Fe-S cluster assembly system in response to the various Fe–S cluster demands remains to be elucidated. In this study, we showed that SufR functions as a transcriptional...
Genetics and Molecular BiologyIdeR, a DtxR Family Iron Response Regulator, Controls Iron Homeostasis, Morphological Differentiation, Secondary Metabolism, and the Oxidative Stress Response in Streptomyces avermitilisIron is essential to almost all organisms, but in the presence of oxygen, iron is both poorly available and potentially toxic. Streptomyces species are predominantly present in soil where the environment is complex and fluctuating. So far, the mechanism of iron homeostasis in Streptomyces spp....