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Genetics and Molecular Biology | SpotlightAcrR and Rex Control Mannitol and Sorbitol Utilization through Their Cross-Regulation of Aldehyde-Alcohol Dehydrogenase (AdhE) in Lactobacillus plantarumThe function and regulation of AdhE in the important probiotic genus Lactobacillus are rarely reported. Here we demonstrated that AdhE is responsible for sorbitol and mannitol utilization and is cross-regulated by two transcriptional regulators in L. plantarum NF92, which had not been reported previously. This is important for...
Evolutionary and Genomic MicrobiologyRapid Parallel Evolution of Azole Fungicide Resistance in Australian Populations of the Wheat Pathogen Zymoseptoria triticiFungicides are essential to control diseases in agriculture because many crops are highly susceptible to pathogens. However, many pathogens rapidly evolve resistance to fungicides. A large body of studies have described specific mutations conferring resistance and have often made inferences about the origins of resistance based on sequencing data from the target gene alone. Here, we show the de novo acquisition of resistance to...
Environmental MicrobiologyMolecular Adaptations of Bacterial Mercuric Reductase to the Hypersaline Kebrit Deep in the Red SeaAnalysis of two structurally homologous but catalytically distinct mercuric reductases from the Kebrit Deep brine in the Red Sea sheds light on the adaptations that enable microorganisms to cope simultaneously with extreme salinity and toxic mercury compounds. One is strongly inhibited by high NaCl concentrations, while the other exhibits NaCl-dependent activation. Their different activity profiles imply that they may derive from...
- Genetics and Molecular BiologyGenome-wide Mutagenesis Links Multiple Metabolic Pathways with Actinorhodin Production in Streptomyces
- Environmental MicrobiologyInterspecies chemical signaling in a methane-oxidizing bacterial community
- Environmental MicrobiologyUsing a Fluorescent Analog of Glucose (2-NBDG) to Identify Which Uncultured Rumen Bacteria Take Up Glucose